Tylosin tartrate

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

酒石酸泰乐菌素是一种大环内酯类抗生素，被批准用于控制家禽支原体病。

Tylosin tartrate is a macrolide antibiotic approved for the control of mycoplasmosis in poultry.(In Vitro):Tylosin tartrate exerts antibacterial effects by binding to 23S rRNA of the bacterial ribosomal 50S subunit .Tylosin tartrate also prevents growth of Gram-negative strains, with MICs of 64 μg/mL, 32 μg/mL, 512 μg/mL and 1 μg/mL for M. haemolytica 11935, P. multocida 4407, E. coli ATCC 25922 and E. coli AS19rlmAI, respectively.(In Vivo):Tylosin tartrate (10-500 mg/kg; s.c.) generally suppresses the elevated TNF-α and IL-1β levels and increases the IL-10 levels in the Lipopolysaccharide (LPS) -treated animals.

Tylosin tartrate exerts antibacterial effects by binding to 23S rRNA of the bacterial ribosomal 50S subunit .Tylosin tartrate also prevents growth of Gram-negative strains, with MICs of 64 μg/mL, 32 μg/mL, 512 μg/mL and 1 μg/mL for M. haemolytica 11935, P. multocida 4407, E. coli ATCC 25922 and E. coli AS19rlmAI, respectively.

Tylosin tartrate (10-500 mg/kg; s.c.) generally suppresses the elevated TNF-α and IL-1β levels and increases the IL-10 levels in the Lipopolysaccharide (LPS) -treated animals. Animal Model:Balb/C mice (2-3 months old, 20-25 g)Dosage:10 mg/kg, 100 mg/kg, 500 mg/kg Administration:Subcutaneous injection Result:Reduced the elevated TNF-α and IL-1β in LPS (250 μg)-treated mice but increased their IL-10 levels.

Tylosin tartrate

Others

Other Targets

Others

Infection

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74610-55-2

1052.16

C46H77NO17·1/2C4H6O6

>98% (HPLC)

Ethanol: 300 mg/mL (281.37 mM); Water: 200 mg/mL (187.58 mM); DMSO: 300 mg/mL (281.37 mM)

O=CC[C@@H](C[C@H]1C)[C@H](O[C@@H]2O[C@H](C)[C@@H](O[C@@H]3O[C@@H](C)[C@H](O)[C@](C)(O)C3)[C@H](N(C)C)[C@H]2O)[C@@H](C)[C@H](O)CC(O[C@H](CC)[C@@H](CO[C@@H]4O[C@H](C)[C@@H](O)[C@@H](OC)[C@H]4OC)/C=C(C)/C=C/C1=O)=O.O[C@H]([C@H](C(O)=O)O)C(O)=O

2-[(4R,5S,6S,7R,9R,11E,13E,15R,16R)-6-[(2R,3R,4R,5S,6R)-5-[(2S,4R,5S,6S)-4,5-dihydroxy-4,6-dimethyloxan-2-yl]oxy-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-16-ethyl-4-hydroxy-15-[[(2R,3R,4R,5R,6R)-5-hydroxy-3,4-dimethoxy-6-methyloxan-2-yl]oxymethyl]-5,9,13-trimethyl-2,10-dioxo-1-oxacyclohexadeca-11,13-dien-7-yl]acetaldehyde (2R,3R)-tartrate salt

(-20℃)

With Ice Pack

≥ 2 years